SHELDON LAB

University of Saskatchewan

Located on Treaty 6 Territory and theHomeland of the Métis

We pay our respect to the First Nations and Métis ancestors of this place and reaffirm our relationship with one another.

PLEASE NOTE: THIS WEBSITE IS CURRENTLY UNDER CONSTRUCTION ⚠️⚠️⚠️

RESEARCH & DISCOVERIES

Current Areas of Study

HISTAMINE AS AN INTERDOMAIN SIGNALLING MOLECULE

Histamine is increasingly being recognized as an intra- and interkingdom signalling molecule with diverse roles in pathogenesis, motility, nutrient acquisition and cell-to-cell communication. We investigate the role of this enigmatic bioamine in bacterial physiology.

ACINETOBACTER-HOST INTERACTIONS

Acinetobacter isolates exhibit a diverse range of responses to the host innate immune response. Using techniques in cellular microbiology, we are investigating how clinical isolates of this multidrug-resistant pathogen interact with the host, host cells, and facets of nutritional immunity.

MORGANELLA MORGANII, AN EMERGING SUPERBUG

Morganella morganii is an emerging, opportunistic, multidrug-resistant pathogen. Almost nothing, however, is known about the factors contributing to its virulence or its success as a One Health pathogen. We have a wide range of investigations into the basic biology and pathogenicity of M. morganii.